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D efinition — A low-grade stromal malignancy of the uterus with preservation of the normal resident endometrial epithelium.
Most cases occur in postmenopausal women in their 60s, but a wide age range has been reported (teenagers to centenarians).
Tamoxifen therapy for breast cancer, as well as prolonged hyperestroginism (either exogenous or endogenous), has been linked to endometrial malignancy, including adenosarcoma.
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