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D efinition — Adenocarcinoma arising in the tubal mucosa.
Historically a small fraction (5% or less) of pelvic serous carcinomas relative to the ovary; however, with the attention being paid to the distal tube (using the section and extensively examine the fimbriated end [SEE-FIM] protocol) as a source of many high-grade serous carcinomas, the incidence is presumed to be much higher.
Linked to chronic tubal inflammation.
Up to 30% have been reported to be associated with BRCA1 or BRCA2 germ-line mutations.
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