Macrophage colony-stimulating factor (M-CSF)

General information

Macrophage colony-stimulating factor (M-CSF) stimulates the growth and differentiation of the monocyte lineage, and promotes the survival, proliferation, and functions of mature monocytes/macrophages [ ]. It also enhances myelopoiesis through the amplified production of G-CSF and GM-CSF by monocytes, and has antitumor activity. Purified human urinary M-CSF and recombinant human M-CSF are under investigation in humans.

Glycosylated mammalian-derived recombinant human macrophage colony-stimulating factor (rhM-CSF) has been used in several trials. Constitutional symptoms (malaise, fatigue, insomnia, headache, nausea, fever, and chills) sometimes occurred. There was no evidence of long-term toxicity during follow-up of patients who received rhM-CSF after allogeneic bone marrow transplantation [ ].

Drug studies