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Ethionamide and protionamide
See also Antituberculosis drugs
General information
Ethionamide is a synthetic derivative of thio-isonicotinamide. The initial oral dosage for adults is 250 mg/day, slowly increasing up to 15–20 mg/kg/day (maximum 1 g/day).
Protionamide is a pyridine derivative of ethionamide. The dosage is 250–300 mg/day.
Ethionamide and protionamide have often proved to be effective in non-tuberculous mycobacterial infections. Acute rheumatic symptoms and difficulty in the management of diabetes have been reported [ ].
Organs and systems
Nervous system
Mental depression, weakness, drowsiness, and hypotension are not rare in patients taking ethionamide or protionamide [ , ]. Other neurological reactions include diplopia, olfactory disturbances, metallic taste, dizziness, paresthesia, headache, and tremor [ ].
Psychological, psychiatric
Psychotic reactions have been described in patients taking ethionamide [ , ] and may be exacerbated by alcohol [ ].
Endocrine
Goitrous hypothyroidism has rarely been described in patients taking ethionamide [ ], with recovery after withdrawal [ ]. Ethionamide inhibits both the uptake of iodine and its incorporation into trichloroacetic acid-precipitable protein [ ].
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