The volume of urine produced per day varies in each individual and is affected by the amount of fluid intake, physiological requirements and insensible losses. Polyuria is arbitrarily defined as urine output of more than three litres in 24 hours.

Causes

Diuretics

Therapeutic

  • Loop – e.g. furosemide, bumetanide

  • Thiazide – e.g. bendroflumethiazide, metolazone, indapamide

  • Amiloride

Osmotic

  • Hyperglycaemia

  • Hypercalcaemia

  • Mannitol

  • Urea

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