Complex Cases in Cartilage Repair: Tricks and Tips


My residents and clinical fellows have often asked me where they can find a well written technique for a medial subvastus exposure as well as the tips and tricks that I use in more complex joint-preserving reconstructions. For this reason I have included a chapter to demonstrate in detail the technique for a medial subvastus exposure and several complex clinical cases that illustrate the principles and techniques involved in joint preservation in more extreme cases. A major improvement in my clinical practice has been in perioperative pain management, which allows me to continue performing these complex cases with minimal hospitalization, reduced patient discomfort, improved satisfaction, and a better initial experience for the patient leading to a quicker recovery.

The other major improvement with autologous chondrocyte implantation (ACI) is the generational change from periosteum to collagen to matrix-induced ACI (MACI). This has made the technique much easier for the surgeon, less invasive for the patient, and I believe improved clinical outcomes will follow. I have included periosteal ACI (pACI), collagen ACI (cACI), MACI, as generation 1, 2, and 3 because they may still exist in different parts of the world. In addition, to have a more comprehensive approach I have included allografts as particulated fresh juvenile articular allograft and fresh large osteochondral allograft.

Medial Subvastus Approach to the Knee: Surgical Technique

Introduction

There has been a recent emphasis on minimally invasive and muscle-sparing approaches in orthopedic surgery. The subvastus approach to the knee joint has been described as an alternative to traditional approaches that involve a large arthrotomy with partial division of the quadriceps mechanism. I have found the technique very useful for joint-preserving surgeries and prosthesis implantations when the soft tissue mobility of the extensor mechanism is supple and a careful surgical technique is pursued as described.

The step-by-step surgical technique for the medial subvastus approach to the knee follows. As with any procedure, patient selection is paramount to success and not all patients are appropriate for this approach. However, in patients who meet our criteria, we feel that this approach offers significant benefit to patients over traditional approaches. These include less postoperative pain and easier, quicker rehabilitation in the early postoperative period. The long-term benefits, if any, are unknown.

Surgical Technique

I perform a medial subvastus approach whenever possible; however, some patients are better served with a standard medial parapatellar approach. Suitable candidates for a subvastus approach must have relatively mobile subcutaneous tissues in order to create a “mobile window” for performing the various aspects of the planned procedure. The mobility of the soft tissues can be assessed during a preoperative clinic visit, but the ultimate decision is made on the day of surgery with the patient under anesthesia. Obesity, contractures, and deformity are relative contraindications; however, with experience, the indications can be expanded. Revision surgery is usually contraindicated because of scar tissue formation and obliteration of tissue planes.

The patient is positioned supine in the standard fashion. We generally use a lateral post at the level of the thigh tourniquet and a post to support the foot, such that the knee can be flexed and maintained at 90 degrees of flexion. The skin incision can be made directly midline or slightly medial to midline, depending on the nature of the pathology. The length of the incision is based on the underlying pathology. Generally, it extends from the superior pole of the patella to the inferior aspect of the tibial tubercle ( Fig. 15.1A ). The incision is carried sharply through the subcutaneous tissue down to the retinacular tissue. Full-thickness medial and lateral flaps are then created sharply with careful hemostasis ( Fig. 15.1B ). The creation of large, full-thickness flaps is important because this allows the extensor mechanism to be mobilized deep to the subcutaneous tissues.

Fig. 15.1, (A) Typical skin incision extending from superior pole of patella to tibial tubercle. (B) Development of medial and lateral full-thickness subcutaneous flaps. (C) Exposure of vastus medialis obliquus (VMO) insertion. (D) Subfascial dissection of VMO. (E) Complete exposure of distal VMO insertion. (F) Placement of Z-retractor underneath distal VMO. Note insertion on patella is left completely intact. (G) Tagging sutures marking distal extent of insertion of VMO on patella. (H) Proposed line of incision for performing medial arthrotomy. (I) Release of synovial attachments from femur to undersurface of quadriceps from medial to lateral. The superior retractor is placed above the synovial attachments and the inferior retractor is intraarticular. This clearly delineates the synovial tissue that must be released to mobilize the extensor mechanism and expose the joint. (J) Exposure of articular surfaces. In this example, a medial unicompartmental arthroplasty is being performed. During total knee arthroplasty, we routinely place a knurled pin in the patellar tendon insertion to protect it from detachment during the case. (K) Standard closure of the arthrotomy. The VMO is left completely intact.

The distal insertion of the vastus medialis obliquus (VMO) on the patella is exposed ( Fig. 15.1C ). The fascia overlying the VMO is released sharply, taking care not to injure any underlying muscle fibers ( Fig. 15.1D ). The fascia is released posteriorly toward the attachment of the VMO on the medial intermuscular septum, which exposes the entire distal extent of the VMO ( Fig. 15.1E ). Using blunt dissection, a finger can be placed underneath the VMO at its inferior border. The VMO is then retracted proximally and laterally while maintaining its attachment to the patella. A Z-retractor is inserted anterior to the distal femur and deep to the muscle to maintain retraction ( Fig. 15.1F ).

Two no. 1 Vicryl marking sutures are placed at the level of the VMO attachment to the patella ( Fig. 15.1G ). An oblique capsular incision is then made just distal to the VMO, beginning posteriorly at the level of the intermuscular septum and extending laterally, parallel to the inferior border of the muscle, toward the medial border of the patella. The incision is made between the marking sutures, which then serve as a guide for later repair. At the medial border of the patella, the arthrotomy is extended distally, taking care to leave a cuff of tissue attached to the patella for closure ( Fig. 15.1H ).

The arthrotomy incision is carried distally across the joint line and parallel to the medial border of the patellar tendon. Care is taken to avoid damaging the anterior horn of the medial meniscus if a biologic procedure is being performed. If necessary, the retropatellar bursa and fat pad can be incised to gain additional exposure.

Next, attention is turned to the suprapatellar pouch where the synovial capsular attachments to the undersurface of the quadriceps tendon are released completely from medial to lateral ( Fig. 15.1I ). This is the key maneuver for being able to mobilize the extensor mechanism fully as it detaches the quadriceps muscle from the anterior femoral synovial supracondylar attachments. After completing this, the patella can then be subluxed into the lateral gutter. Creating a large, full-thickness, lateral subcutaneous flap during the initial exposure is necessary to create a pocket into which the patella can be subluxed. A 90-degree bent Hohman or Z-retractor is placed in the lateral gutter at the level of the quadriceps tendon insertion above the patella to maintain retraction of the patella. Flexing the knee to approximately 90 degrees provides excellent exposure of the entire joint and the appropriate procedure can be performed ( Fig. 15.1J ). A standard closure is performed at the end of the case ( Fig. 15.1K ). The closure is quite simple because no muscle needs to be repaired.

Discussion

The medial subvastus approach was originally described in the German literature by Erkes in 1929. A modified version was re-introduced by Hoffman in 1991. A so-called “mini” subvastus approach has since been described. There are currently multiple reports in the literature describing the results with respect to total knee arthroplasty. Although concerns have been raised regarding appropriate component positioning, many studies demonstrate more rapid recovery, better pain scores, less blood loss, and better short-term knee range of motion when comparing the subvastus approach with more traditional appproaches. Recently, Schroer et al. published their results of 600 primary total knee arthroplasties performed through a subvastus approach. Follow-up was short-term, averaging 28 months. A historical group of 150 total knee arthroplasties performed through a standard medial parapatellar arthrotomy was used as a control. Overall, there were 11 major complications (1.8%) requiring reoperation in the subvastus group and 6 (4.0%) in the traditional group. The rate of both major and minor complications was found to be independent of surgical technique. The rate of major complications in the subvastus group was found to be associated with surgical experience; the rate was reduced by 16% for each additional 50 procedures performed. Mean knee flexion after 1 year averaged 125 degrees in the subvastus group and 114 degrees in the traditional group. Average operative time was initially higher in the subvastus group, but decreased with experience so that it was less than the traditional group in the last 400 subvastus procedures performed. Of note, the authors stated that 99% of total knee arthroplasties performed during the study period were done through a subvastus approach with 91% of patients classified as overweight and 11% as morbidly obese.

We have found the subvastus approach to provide excellent exposure and allow quicker advancement of rehabilitation after knee surgery. As with any procedure, there is a definite learning curve associated with the subvastus approach. My technique and indications have evolved with time and experience. Less emphasis is placed on the length of the skin incision and more emphasis placed on careful dissection of large medial and lateral skin flaps and atraumatic mobilization of the muscle. In addition to total knee arthroplasty and medial unicompartmental knee arthroplasty, we have applied the subvastus approach to the treatment of other intraarticular pathologies, primarily chondral defects. Procedures such as autologous chondrocyte implantation and osteoarticular allografts can easily be performed through this approach.

Perioperative Pain Management

Perioperative pain management is essential for the initial perception of the patient’s comfort and well-being as well as postoperative range of motion and avoiding stiffness. As mentioned in earlier chapters, choosing a patient who does not have addictive behavior is important. Weaning patients off narcotics, alcohol, or tobacco is essential prior to surgery.

At the time of surgery, preoperative preemptive analgesia can be helpful with the use of preoperative oral Tylenol 650 mg and Celebrex 200 mg as well as intravenous Decadron and intravenous TXA-Transemic Acid to manage bleeding. I use intravenous Decadron 6 mg, TXA 1 g, and intravenous antibiotics at the onset of surgery. The anesthesiologist then administers 1 g of TXA at the end of surgery. (Of course, prior DVT, pulmonary embolus, or stroke are contraindications to TXA.)

Prior to wound closure, I use a pericapsular infiltration that I have been utilizing successfully for all open knee surgeries since 2010. This eliminates the need for regional blocks and I prefer a general anesthetic with minimal gas inhalation and mostly TIVA-total intravenous anesthesia. Patients will awaken quickly, comfortably, and with minimal pain especially after the local infiltration.

The medications in the injection solution are mixed by the pharmacy and delivered to the operating room labeled with the patient’s name. The total volume is 100 cc: 80 mcg clonidine, 0.5 mg epinephrine, 30 mg Ketorolac, 49.25 mL 0.5% ropivacaine, mixed with normal saline to a final volume of 100 ml.

I use an 18-gauge spinal needle or 22-gauge spinal needle in large 30 or 60 mL syringes and infiltrate everything that is pain-sensitive. This includes the periosteum and synovium circumferentially around the femur, the tibia, the quadriceps, the subcutaneous envelope, and specifically along the medial intermuscular septum at the site of the saphenous nerve exiting anteriorly over the anterior knee. When injecting, I first aspirate, especially over the saphenous nerve, to ensure that the mixture will not be injected into a blood vessel. The other point of caution is to be careful laterally and stay away from the peroneal nerve where a postoperative nerve palsy can occur as a result of the injection of ropivacaine. I have found this block to be extremely successful in alleviating pain from 24 to 72 hours postoperative before it dissipates, after which time it is easy to manage postoperative pain by transitioning to oral pain medications.

In addition, a continuous ice cryotherapy system is placed around the knee on top of a light dressing and sent home with the patient to assist in swelling and pain management.

c-ACI-Multiple Defects Salvage Case With HTO-TTO

A 33-year-old occupational therapist has had several years of left pain, recurrent effusions, and grinding. She reports a prior medial meniscectomy and chondroplasty surgery of the left knee. Activities that she cannot perform include hiking, yoga, and Zumba.

Varus alignment is present on the limb alignment x-ray images with the mechanical axis line falling through the center of the medial tibial plateau. There is narrowing of medial cartilage joint spaces ( Fig. 15.2A–E ).

Fig. 15.2, (A) Long alignment x-ray image demonstrates weight-bearing axis to fall through the center of the medial joint compartment. (B) Standing AP x-ray image demonstrates loss of joint space anterior in the medial compartment. (C) Standing PA x-ray image demonstrates well-preserved posterior medial joint compartment. (D and E) Well-preserved patellofemoral joint space of both knees. (F) Large articular defects noted on the medial femoral condyle, medial tibial plateau, lateral femoral condyle, and trochlea. The exposure is facilitated by a tibial tubercle osteotomy that has been flipped up and a takedown of the medial meniscus. (G) Radical debridement of all the articular cartilage is performed back to stable intact full-thickness cartilage. The blue dots represent the location of transosseous drill holes made to secure the collagen membrane and chondrocytes using a small C-wire on a wire driver. The sutures are passed by straightening out the P3 cutting needle with a needle driver. (H) Final appearance of c-ACI after microsuturing, sealing the areas with fibrin glue, and injecting autologous cultured chondrocytes to fill the defects. The medial meniscus is then brought back to the intermeniscal ligament in near full extension and repaired with transosseous sutures through the medial meniscus anteriorly through the metaphyseal bone with a tapered needle no. 1 Vicryl suture. The tibial tubercle is then repositioned to center patellar tracking and fixated with two anterior to posterior lag screws followed by the medial patellofemoral ligament reattached to the mid-patellar pole and the lateral retinaculum being lengthened. Postoperative range of motion is instituted the morning after surgery using patellar mobilizations with manual therapy and a continuous passive motion machine. Touch weight-bearing for 6 weeks was followed by progressive weight-bearing to full body weight at 10 weeks with a medial compartment unloader braces. Because of the lateral femoral condyle defect the axial alignment is not overcorrected into the lateral compartment but just brought back to the midline. (I) Preoperative standing AP x-ray image shows loss of the anterior medial joint space with bone-on-bone changes. (J) Four-year postoperative weight-bearing x-ray image showing complete restoration of the medial joint compartment. It is a full weight-bearing AP x-ray image with mechanical axis corrected to the midline and not into the lateral compartment because of the lateral femoral condyle transplant. (K) VAS scores preoperative and postoperative.

ACI (autologous cultured chondrocytes) using four vials of Carticel (Genzyme, Cambridge, MA, USA) with Bio-Gide membrane (Geistlich Industries, Wolhusen, Switzerland) was performed to the medial femoral condyle anterior (40 × 20 mm), posterior (25 × 15 mm), medial tibial plateau (25 × 15 mm), lateral femoral condyle (15 × 15 mm), trochlea (30 × 20 mm) combined with an opening wedge tibial valgus osteotomy and a tibial tubercle anteromedialization osteotomy ( Fig. 15.2F–H ).

Four years after surgery, the medial joint space is restored as seen in postoperative AP x-ray examination ( Fig. 15.2I–J ). Six years after surgery, the patient is doing well with a 96.4 KOOS score (preoperative 61.3) ( Table 15.1 ), VAS score of 2 (preoperative 6) ( Fig. 15.2K ), and modified Cincinnati rating of 10 (preoperative 5) ( Table 15.2 ). The patient reports full return of her knee function with minimal discomfort and has resumed recreational activities, including hiking, yoga, and even sports, and work without pain.

Table 15.1
KOOS Scores Preoperative and 6 Years Postoperative
Preoperative 6 years postoperative
Subtotal symptoms and stiffness: 46.43% 96.43%
Subtotal pain: 61.11% 97.22%
Subtotal function, daily living: 83.82% 100.00%
Subtotal function, sports and recreational activities: 30.00% 85.00%
Subtotal quality of life: 31.25% 93.75%
Total KOOS: 61.3 96.4%

Table 15.2
Modified Cincinnati Health Survey Overall Score Preoperative and 6 Years Postoperative
Modified Cincinnati Health Survey
Poor (1–2) I have significant limitations that affect activities of daily living.
Fair (3–4) I have moderate limitations that affect activities of daily living. No sport possible.
Good (5–6) I have some limitations with sports but I can participate; I compensate.
Very good (7–8) I have only a few limitations with sports.
Excellent (9–10) I am able to do whatever I wish (any sport) with no problem.
Preoperative : 5 and 6 years postoperative : 10

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