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Greater in infants and children
Greater in longer, larger operations
Similar in RA and GA
Surgical wound infections
Coagulopathy
Reduced drug metabolism
Prolonged recovery and hospitalization
Shivering and thermal discomfort
Benefits:
Improved neurologic recovery in asphyxiated neonates
Decreases triggering and severity of malignant hyperthermia.
Core temperature normally protected by responses that include sweating, vasoconstriction, and shivering.
Typical doses of GA have little effect on the sweating threshold but decrease vasoconstriction and shivering thresholds 2–4° C, thus increasing the range of temperatures not triggering protective responses 10-fold from approximately 0.4–4° C.
RA inhibits thermoregulatory control by preventing peripheral responses (such as vasoconstriction) and centrally by reducing afferent input.
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