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Succinate dehydrogenase-deficient renal cell carcinoma
Definition
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A variant of renal cell carcinoma (RCC) defined by the loss of protein expression of succinate dehydrogenase B on immunohistochemistry
Clinical features
Epidemiology
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Rare, <0.2% of all RCCs
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Mean age, 38 years (range, 14–76)
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Male to female ratio, 1.8:1
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Majority of cases occur in the setting of germline mutations in one of the succinate dehydrogenase (SDH) genes, most commonly SDHB
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