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Carcinoma derived from the urothelial lining of the urinary tract that invades into the underlying tissues
Urothelial carcinoma occurs most often in the urinary bladder with lower incidence in the kidneys, ureters, and urethra.
Urothelial carcinoma is the most common type of bladder cancer in the United States.
Males are affected three- to fourfold more frequently than are females.
Smoking and occupational exposure to aromatic amines are the most significant risk factors.
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