Transforaminal Lumbar Interbody Fusion (TLIF)


Introduction

Posterior lumbar interbody fusion techniques have been popular since the 1950. Specifically, posterior lumbar interbody fusion (PLIF) was a very popular technique; however, it required removal of both facets in order to achieve adequate graft positioning. To surpass the inherent limitations of the PLIF, Harms and Rollinger, in 1982, described the placement of the interbody bone graft via a transforaminal approach. In the transforaminal lumbar interbody fusion (TLIF) procedure, bone graft and an interbody spacer are placed via a posterolateral transforaminal route into a distracted disk space in conjunction with a supplemental pedicle screw construct. This TLIF approach allows less retraction of the thecal sac and neural structures; it spared the contralateral lamina and facet (vs. PLIF) providing a bigger surface for fusion. Additionally, advantages of the TLIF over PLIF are fewer complications, elimination of epidural scarring, and less intraoperative bleeding. Furthermore, given TLIF’s unilateral approach, preservation of the lumbar spine musculoligamentous complex is obtained. Recently some variations of the open TLIF have been described, such as the mini-open TLIF for a single-level approach. Despite the introduction of the minimally invasive TLIF (MIS TLIF), open TLIF is still routinely used in many centers owing to the high bony fusion achieved (>90%) and similar complications rate when compared with MIS TLIF.

Surgical Indications and Technique

Indications

The primary objective of any interbody fusion is to stabilize the spine. Table 8.1 shows the indications for lumbar interbody fusions. Table 8.2 presents the relative contraindications for the procedure.

TABLE 8.1
Indications for Lumbar Interbody Fusion
Adapted from Winn HR, Kliot M, Brem H. Youmans Neurological Surgery . Philadelphia, Elsevier Saunders; 2003
  • Spondylolisthesis (Grade I or II)

  • Degenerative disk disease causing discogenic back pain

  • Recurrent lumbar disk herniation with significant mechanical back pain

  • Postdiskectomy collapse with neural foraminal stenosis and radiculopathy

  • Recurrent (third time or more) lumbar disk herniation with radiculopathy (with or without back pain)

  • Pseudoarthrosis

  • Postlaminectomy kyphosis

  • Traumatic instability

  • Lumbar deformity (with coronal and/or sagittal plane imbalance)

TABLE 8.2
Relative Contraindications for Lumbar Interbody Fusion
Adapted from Mummaneni PV, Rodts GE, Jr. The mini-open transforaminal lumbar interbody fusion. Neurosurgery . 2005;57(4 Suppl):256–261; discussion 261; and Mummaneni PV, Haid RW, Rodts GE. Lumbar interbody fusion: state-of-the-art technical advances. Invited submission from the Joint Section Meeting on Disorders of the Spine and Peripheral Nerves, March 2004. J Neurosur Spine . 2004;1(1):24–30.)
  • Multilevel (>3 levels) degenerative disk disease (except in deformity cases)

  • Single-level disk disease causing radiculopathy without symptoms of mechanical low back pain or instability

  • Severe osteoporosis

Technique

The patient is first placed under general anesthesia, intubated, and then positioned prone on a radiolucent surgical table ( Fig. 8.1 ). Intravenous antibiotics should be administered prior to performing the skin incision. The surgeon must avoid placing the patient in a flat-back or kyphotic position before performing the TLIF, because the patient may be fused into that nonphysiologic position. Positioning the patient in optional lordosis is accomplished by providing maximal hip extension during positioning. Pressure points are appropriately padded, and the surgical field is prepared and draped in a sterile fashion. Biplanar fluoroscopy may then be used to localize the indexed level accurately. A vertical incision (5–7 cm) is performed and the muscles and soft tissues are retracted laterally to expose the spinous processes, lamina, facet joints, and transverse process ( Fig. 8.2 ). A laminectomy, facetectomy, or both are performed, depending on the clinical presentation. Minimally, a unilateral laminotomy and partial facetectomy are performed on the more symptomatic side. The exiting nerve root is identified and carefully preserved.

Fig. 8.1, The patient is placed prone on a radiolucent table; bony prominences are properly padded. Fluoroscopy is suggested for localization to avoid wrong level surgery at three different time points: (1) previous to the incision and confirmation; (2) after bone exposure; and (3) before the diskectomy.

Fig. 8.2, During a transforaminal lumbar interbody fusion open approach, proper identification of the index level should include the following: the superior and inferior spinous processes, lamina, articulating processes, and transverse processes. An angled curate can be inserted below the spinous process immediate to the indexed level to be used as a marker while taking x-rays for adequate localization.

Once the neural elements are adequately decompressed, pedicle screws are placed in a standard fashion. The disk space is then identified and a standard diskectomy is performed. Adequate removal of the cartilaginous endplate is necessary; however, preservation of the bony endplates is required to prevent graft subsidence. With the use of a combination of interspace wedges and serial distraction of the pedicle screws, an increase in disk height is accomplished and maintained ( Fig. 8.3 ).

Fig. 8.3, Yellow ligament resection and lateral recess bony decompression can be performed under interlaminar manual distraction. This is especially helpful for those cases with severe degeneration. Automatic interlaminar retractors can be used as well. Once the nerve root of interest or both nerve roots have been decompressed, disk identification and diskectomy are performed.

An interbody graft of the adequate size is prepared and packed with autograft or other fusion substrate. A nerve retractor is placed against the traversing nerve root to protect it during graft placement while always trying to minimize the retraction of the thecal sac. The first cage is impacted until it is just under the posterior edge of the vertebral body. It is important to begin moving the cage medially just as it sinks within the disk space. This allows the mesh to be placed across the vertebral body, making room for the second cage on the ipsilateral side ( Figs. 8.4 and 8.5 ).

Fig. 8.4, After diskectomy, the cage trial is inserted. Special attention while impacting the cage trial must be taken because excessive force may cause endplate fractures that may lead to subsequent subsidence and pseudoarthrosis.

Fig. 8.5, The cage is inserted first, in an almost perpendicular direction to the floor/patient, and then the handle is tilted outward to direct the cage medially and anteriorly. Bone chips can be used as graft before the cage is inserted to promote fusion.

After the interbody construct is placed, the pedicle screws are attached to and compressed on the rod, thereby restoring lumbar lordosis while maintaining the restored disk height. This restores lordosis and compresses the interbody graft to prevent graft migration and facilitate fusion.

A multilayer closure is performed using absorbable sutures in the lumbodorsal fascia and subdermis. Staples or nylon sutures are used to close the skin.

Limitations

As opposed to other types of interbody fusion, open TLIF is versatile. The main limitations of the procedure are on the number of levels applied and the greater risk of failure in the osteoporotic spine. Although a TLIF may be applied at all levels of the lumbar spine, it is generally indicated for one to three levels. At more than this number of levels, the time to perform such a procedure may be excessive. Moreover, care must be taken when performing TLIF at the upper lumbar levels. As one approaches the conus medullaris, there is less retraction of the thecal sac (i.e., dura), thus limiting TLIF at L1-2 and potentially L2-3.

The chance of endplate damage is greater in the osteoporotic spine. If this occurs during endplate preparation or cage placement, subsidence may occur and hence construct failure. If TLIF is used in the setting of osteoporosis, significant care must be utilized during endplate preparation and implant placement.

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