Key Points

Background

  • A useful psychiatric diagnostic system allows clinical and research endeavors to flourish.

  • The DSM-5, the most common diagnostic system used in the United States, encourages evaluation and description of multiple kinds of information: psychiatric, medical, and psychosocial.

  • Careful use of the DSM-5 can promote rigorous conceptualization of psychiatric issues and enhance clinical communication.

History

  • DSM-5, released in May 2013, is the most recent revision to our psychiatric diagnostic system.

  • Several new disorders were added to DSM-5, while diagnostic criteria for others were revised.

Clinical and Research Challenges

  • As part of an evolving diagnostic system, the DSM-5 remains subject to future revision based on new research findings and changing diagnostic frameworks.

Practical Pointers

  • Diagnostic formulation using the DSM-5 is an ongoing process that requires clinical judgment and skill.

DSM-5 in Context: an Evolving Diagnostic System

Psychiatric diagnostic classification serves a variety of purposes. Diagnosis marks the borders between mental disorders and non-disorders (such as normal personality variations) and between one type of disorder and another. Diagnostic schemata have practical implications for helping clinicians to conceptualize psychiatric issues, to communicate with patients and other clinicians, and, ideally, to make prognostic predictions and to plan effective treatments. A useful diagnostic system also enables psychiatric research to flourish. It permits valid and reliable classification of diseases that may benefit from basic research. Efforts to document, describe, and classify mental illness go back thousands of years; they include attempts to group diseases by cross-sectional phenomenology, by theories of causation, and, later, by clinical course.

In the United States, the diagnostic system in widest use is the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5). The DSM has been increasingly disseminated internationally. The World Health Organization's (WHO) International Statistical Classification of Diseases and Related Health Problems, Tenth Revision (ICD-10) is also in wide use internationally. The ICD is used in the United States for coding purposes within medical billing systems, with a switch from the previous version, the International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM) to the ICD-10 planned for 2014, and subsequently delayed to October 2015.

The DSM-5, released in 2013, represents the latest in an ongoing process of change in our psychiatric diagnostic system. While the original Diagnostic and Statistical Manual: Mental Disorders was published in 1952, the transition from the second edition (DSM-II) to the third edition (DSM-III) represented a major shift in the approach to psychiatric diagnosis. Psychodynamic formulations were no longer intrinsic to diagnostic categorization, and the DSM-III was considered to be atheoretical and descriptive in orientation, using a multi-axial diagnostic system. As subsequent revisions were made, there were increasing efforts to ensure diagnostic reliability and validity, to incorporate research findings, and to gather new information via field trials.

Prior to the advent of DSM-5, the DSM-IV, and its subsequently updated text revision (DSM-IV-TR) continued to use the multi-axial diagnostic system. Axis I contained all psychiatric disorders except for the personality disorders and mental retardation, which were recorded on Axis II. Axis III listed non-psychiatric medical illnesses. Psychosocial and environmental problems were listed on Axis IV. The Global Assessment of Functioning (GAF), a numerical value summarizing the patient's current degree of psychosocial, occupational, and educational impairment, was recorded on Axis V. For some applications, the DSM-5 is being gradually phased in to full use. For example, the DSM-IV-TR criteria will continue to be used for psychiatric board certification examinations until 2017. Therefore, although the multi-axial system has been eliminated in DSM-5, familiarity with DSM-IV-TR constructs may continue to be relevant for some time in clinical and research contexts.

The Process of Change for DSM-5

Even as DSM-IV-TR was being published, efforts had begun to consider improvements for DSM-5. DSM-IV-TR's Appendix contained diagnostic criteria sets for potential inclusion in future editions. Additional suggestions for change reflected advances in psychiatric research, or appeals based on clinical utility. The American Psychiatric Association (APA), the WHO, the World Psychiatric Organization, the National Institutes of Mental Health, and the National Institute on Alcoholism and Alcohol Abuse were all active in the preparation phase for DSM-5. Work groups in the APA's DSM-5 Task Force made proposals for revisions, field trials were conducted, and public and professional commentary was elicited. A Scientific Review Committee provided peer review, and a Clinical and Public Health Committee, as well as forensic and statistical consultants weighed in regarding proposed changes. In addition, efforts were made to coordinate the format of DSM-5 with the anticipated updating of the ICD-10 to ICD-11, resulting in structural changes to the groupings of disorders in the DSM.

The Three-Section Structure of DSM-5

Section I

DSM-5 is divided into three sections. Section I provides a history of the DSM and guidance for its use. Of note, DSM-5 diagnostic criteria are not meant to be rigidly applied to mandate or exclude individuals from treatment when clinical circumstances dictate otherwise. In addition, given that DSM-5 has been created primarily for use in health care and research, it is not intended to be sufficient for making legal determinations. In all settings, clinical judgment must be applied in gathering and interpreting diagnostic information, ensuring the presence of distress or functional impairment, and incorporating all available data into a clinical formulation.

Section II

Section II lists DSM-5 diagnoses and codes, separated into categories of related disorders. Disorders are described beginning with those which have a neurodevelopmental origin early in the life span, and ending with diseases that most often appear late in life. Within the developmental framework, disorders have also been grouped according to current neuro-scientific understanding that links disorders based on shared genetic findings (i.e., between bipolar and psychotic disorders), clinical courses, and patterns of co-morbidity. Variability and changes in presentation that occur through the life span—such as the age-dependent change in hyperactive symptoms that typically occurs in attention-deficit/hyperactivity disorder (ADHD)—are also included for individual disorders under the subheading of “Development and Course.” Gender-related factors that may have an impact on risk, presentation, or clinical course are incorporated throughout Section II as “Gender-related Diagnostic Issues.” These two new sub-sections were added to highlight the importance of development and gender in psychiatric diagnosis.

When determining which diagnoses best fit a particular patient, one must consider which diagnoses are hierarchical and mutually exclusive, and which may be co-morbid/co-existing at the same time. For example, a patient may have a separation anxiety disorder beginning in pre-school, develop impairing social phobia in early adolescence, and then experience a specific phobia of heights following a trip to the Grand Canyon during high school, resulting in three co-morbid anxiety disorders at the time of presentation at age 15. Alternatively, the adjustment disorders exclude other diagnoses, as the clinician must determine that the presenting symptoms do not fulfil criteria for another psychiatric disorder. Likewise, a non-psychiatric medical or substance-induced etiology must typically be ruled out to clinical satisfaction before any other disorder can be diagnosed.

A procedure is needed to describe disorders that, although clinically significant, do not fit neatly into the major diagnostic categories, or where more data are required before assigning a more precise diagnosis. In DSM-IV-TR, “Not Otherwise Specified (NOS)” diagnoses were used for this situation; for example, “eating disorder NOS” could be used for patients who did not meet full criteria for either anorexia nervosa or bulimia nervosa. In DSM-5, NOS diagnoses have been eliminated. Instead, clinicians can use the term “other specified” when wishing to indicate the reason that full diagnostic criteria are not met ( Box 17-1 ). “Unspecified” can be used when a disorder is clearly present, but no specific reason is given for not meeting full criteria. This situation could occur when insufficient historical information is available, as in an emergency evaluation of a patient. The “unspecified” label can be used to broadly indicate the presence of a psychiatric disorder (e.g., unspecified mental disorder), or, when possible, to place a diagnosis within a certain family of disorders (e.g., unspecified bipolar and related disorder) (see Box 17-1 ). Another option to signal diagnostic uncertainty is to mark a diagnosis as provisional, meaning that the selected diagnosis is expected to emerge more clearly over time or with additional information.

Box 17-1
“Other Specified” and “Unspecified” Diagnoses
Case Examples

Example 1: Other Specified Diagnosis

A 20-year-old man is seen for an intake appointment at an outpatient clinic. He reports significant distress about his prominent acne scars. He spends at least 4 hours every day examining his skin in the mirror, and picking at the skin around his scars. He has been unable to attend college or keep a job for the past 3 years due to this behavior and his appearance concerns. He is diagnosed with “other specified obsessive-compulsive and related disorder: body dysmorphic-like disorder with actual flaws.”

Example 2: Unspecified Diagnosis

A 25-year-old female is brought into the emergency room by an ambulance after some passers-by called 911. She had been running through the streets, dressed in only a nightgown, yelling that “Judgment Day is coming.” On exam, she was noted to be extremely distractible and she had rambling and voluminous speech. Her mood was irritable, and her affect was labile. She reported hearing the voice of God telling her that Judgment Day was near. She also reported delusions that her neighbors were demons sent by Satan to monitor her whereabouts until the Time of Judgment. The patient was unable to report any prior psychiatric or medical history, the time course of her current symptoms, or any recent alcohol or substance abuse. In the ER, she was given working diagnoses of: Unspecified bipolar and related disorder; Unspecified schizophrenia spectrum and other psychotic disorder.

The patient is admitted to the hospital's inpatient psychiatric unit. Her laboratory results are within normal limits, and her toxicology screens are negative. All subsequent medical work-up is negative. The patient's parents, with whom she was close, provided the following collateral information: For the past 2 weeks, the patient had been acting strangely. She slept only a few hours a night, and then stopped sleeping altogether. She was very irritable, and quick to anger. She complained that her thoughts were racing, and she was much more talkative than usual. She was also highly distractible. The day prior to her ER visit, she told them she was hearing God speak to her. She had one prior episode of depression in adolescence, and had never heard voices or been paranoid before. She had normal function until 2 weeks prior to admission. At the time of discharge, her diagnosis was modified to bipolar I disorder, with psychotic features, most recent episode manic.

Specifiers may also be added to diagnoses to provide additional information about the clinical course, features, and severity. For many diagnoses, current severity can be indicated with specifiers (i.e., mild, moderate, or severe). When symptoms have substantially improved, the specifiers “in partial remission” or “in full remission” are sometimes used. Some disorders have their own specifiers listed in DSM-5, such as “with dissociative fugue” for dissociative amnesia. Others have various mutually-exclusive subtypes, such as blood-injection-injury type or natural environment type for specific phobia. The DSM-5 Appendix provides a guide for representing specifiers or subtypes via the final digits of the ICD-9-CM or ICD-10 diagnostic codes.

As noted above, the multi-axial format has been eliminated in DSM-5. All psychiatric and medical diagnoses that are relevant to care should be listed in order of clinical concern, with the most important diagnosis prompting the clinical encounter listed first. These may include diagnoses involving the interplay between medical and psychiatric conditions. For example, substance ingestion may be thought to cause the psychiatric problem, resulting in a diagnosis such as “substance-induced psychotic disorder.” Alternatively, a medical illness can be understood as provoking the mental disorder, leading to a diagnosis in the format “[psychiatric disorder] due to [another medical condition]” ( Box 17-2 ). Subthreshold psychiatric symptoms (e.g., anxiety or over-eating), personality traits or defenses, maladaptive coping (e.g., non-adherence to medical care) or physiological stress responses that have a negative impact on the course of a medical condition are given a diagnosis of “psychological factors affecting other medical conditions” (see Box 17-2 ). In addition “other conditions that may be the focus of clinical attention” may be listed, including as many problems or stressors as are relevant to diagnosis and clinical management ( Table 17-1 ). These conditions are typically listed with their corresponding ICD code (V codes for ICD-9, Z codes for ICD-10).

Box 17-2
The Interplay between Psychiatric and Medical Conditions

Example 1: Psychiatric Disorder Due to a Another Medical Condition

A 38-year-old woman with no prior psychiatric history develops new panic attacks, weight loss, and heat intolerance over several months, resulting in problems at work; she is found to have an abnormally low thyroid-stimulating hormone level. Given the assumption that the panic attacks have been precipitated by the thyrotoxic state, the diagnostic assessment might look as follows:

  • 1.

    Hyperthyroidism

  • 2.

    Anxiety Disorder due to Hyperthyroidism, with Panic Attacks

  • 3.

    Discord with work supervisor

Example 2: Psychological Factors Affecting Other Medical Conditions

A 38-year-old woman with no prior psychiatric history is diagnosed with ovarian carcinoma after a pelvic ultrasound performed in the course of an infertility evaluation. Following surgery, she develops a pattern of missing chemotherapy treatments, which she attributes to forgetting or her busy schedule. Despite repeated feedback from her oncologist, she continues to downplay the effect delaying treatment could have on her prognosis. Neither the carcinoma itself, nor the adverse cognitive effects of treatment, is believed to be directly causing this behavior, although there is concern that stressful discussions with her husband over adopting a baby may be contributory, and her avoidance is clearly interfering with consistent cancer treatment. At work, she has had a pattern of avoiding help from her supervisor during critical projects, but she does not meet criteria for an anxiety disorder, personality disorder, or other mental disorder. Given this diagnostic formulation, the diagnostic assessment in this case could be as follows:

  • 1.

    Stage IA clear-cell epithelial carcinoma of the left ovary

  • 2.

    Psychological factors affecting treatment of ovarian carcinoma

  • 3.

    Infertility

TABLE 17-1
Other Conditions That May Be a Focus of Clinical Attention
Problem Examples
Primary support group Disruption of family by separation or divorce
Relationship distress with spouse or intimate partner
Uncomplicated bereavement
Social environment Acculturation difficulty
Social exclusion or rejection
Occupational Adverse effect of work environment
Unemployment
Housing Homelessness
Discord with neighbor, lodger, or landlord
Economic Low income
Extreme poverty
Insufficient social insurance or welfare support
Legal Imprisonment or other incarceration
Victim of crime
Other psychosocial/environmental Religious or spiritual problem
Exposure to disaster, war or other hostilities

Section III

Section III contains a collection of new material. Analogous to Appendix B of DSM-IV-TR, Section III lists candidate disorders that require additional research before consideration for inclusion in future revisions. These include such constructs as Internet Gaming Disorder and Non-suicidal Self-Injury.

In addition, Section III presents a Cultural Formulation Interview to assist in gathering culturally-relevant information affecting diagnosis and treatment-planning with diverse populations. DSM-5 introduces a more fine-grained approach to understanding how culture may impact clinical care to replace the “culture-bound syndromes” of DSM-IV-TR. A glossary in the appendix describes important cultural concepts of distress. These include cultural syndromes (such as ataque de nervios ), cultural idioms of distress (such as kufungisisa ), and cultural explanations (such as maladi moun ). Information on cultural variation in clinical presentations is also included in the description of specific disorders in Section II. For example, in the discussion of pica, it is noted that some groups may ascribe spiritual value to the eating of specific non-food substances, which should not be diagnosed as a mental disorder.

A major critique of DSM-IV-TR focused on limitations of the categorical model and encouraged the inclusion of dimensional approaches in future editions. Based on these critiques, DSM-5 offers incremental changes toward a dimensional model of diagnosis. A standardized measure of “cross-cutting symptoms,” such as anger and sleep problems, which appear in multiple psychiatric disorders, is featured in Section III of the DSM-5. In addition, a dimensional measure of psychosis symptom-severity is included. Given that the GAF has been removed from DSM-5, an alternative measure for assessing disability, the WHO Disability Assessment Schedule 2.0 (WHODAS 2.0) is provided.

Work has also been conducted along dimensional lines in the area of personality disorders research. Although the APA opted to keep the system for diagnosing personality disorders unchanged in Section II of DSM-5 ( Table 17-2 ), a different way to conceptualize personality disorders is introduced in Section III. This model considers four areas of personality functioning: identity, self-direction, empathy, and intimacy. In addition, personality traits falling within one of five domains (for example, negative affectivity) are assessed, each featuring more specific “trait facets” (such as emotional lability or hostility).

TABLE 17-2
Personality Disorders
Cluster A Paranoid Personality Disorder
Schizoid Personality Disorder
Schizotypal Personality Disorder
Cluster B Antisocial Personality Disorder
Borderline Personality Disorder
Histrionic Personality Disorder
Narcissistic Personality Disorder
Cluster C Avoidant Personality Disorder
Dependent Personality Disorder
Obsessive-Compulsive Personality Disorder

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