Objectives This chapter will: 1. Describe the current modalities currently available for pediatric continuous renal replacement therapy, giving context to the differences and indications for peritoneal dialysis and extracorporeal dialysis. 2. Present some general rules to follow to rationally prescribe…
Objectives This chapter will: 1. Describe the clinical manifestation of pediatric multiple organ dysfunction syndrome (MODS), including pathogenetic pathways and specific pediatric MODS causes. 2. Detail theoretic mechanisms of organ damage and current literature available in this field. 3. Present…
Objectives This chapter will: 1. Review the cause of pediatric acute kidney injury, correlated with reversibility and outcome. 2. Outline the components of conservative management of pediatric acute kidney injury. 3. Present an approach to dialytic management of pediatric acute…
Objectives This chapter will: 1. Describe different renal replacement strategies and their clinical effects on critically ill patients. 2. Review the benefits and side effects of continuous renal replacement therapies. 3. Compare the clinical effects of continuous therapies with those…
Objectives This chapter will: 1. Help the reader understand the concept of clearance and the manner in which it is applied to estimate dose of renal replacement therapy. 2. Describe the differences in the use of urea kinetic modeling (UKM)…
Objectives This chapter will: 1. Describe the main dimensions of renal replacement therapy (RRT) dose: efficiency, intensity, and clinical efficacy. 2. Describe the most important studies addressing the impact of RRT dose on the survival of critically ill patients. 3.…
Objectives This chapter will: 1. Approach the concept of multi-organ support therapy focusing on the combined pulmonary-renal dysfunction in terms of incidence, extracorporeal support, and outcomes. 2. Describe technologies available to combine extracorporeal membrane oxygenation (ECMO) systems with continuous renal…
Objectives This chapter will: 1. Review the pathophysiology of diastolic dysfunction and the complex interaction between the heart and the kidney in the context of cardiorenal syndromes (disorders of the heart and kidneys in which acute or chronic dysfunction in…