Tag Ximing J. Yang MD PhD

Urethral caruncle

Definition A polypoid inflammatory lesion involving the distal urethra, particularly the posterior urethral orifice Clinical features You’re Reading a Preview Become a Clinical Tree membership for Full access and enjoy Unlimited articles Become membership If you are a member. Log…

Testicular lymphoma

Definition Malignant neoplasm of lymphocytes arising from or involving the testis Clinical features You’re Reading a Preview Become a Clinical Tree membership for Full access and enjoy Unlimited articles Become membership If you are a member. Log in here

Germ cell neoplasia in situ

Definition Gonocyte-like germ cells with abundant clear cytoplasm and large nuclei with coarse chromatin and expressing embryonic germ cell markers, located in the basilar aspect of the seminiferous tubules; considered to be the precursor of the majority of malignant testicular…

Renal angiomyolipoma

Definition A mesenchymal neoplasm composed of variable proportions of abnormal blood vessels, cells with smooth muscle features and adipose tissue; believed to be derived from perivascular epithelioid cells (PEC); hence, also named PECOMA Clinical features Epidemiology Angiomyolipoma (AML) accounts for…

Renal cell neoplasms in Birt-Hogg-Dubé (BHD) syndrome

Definition An autosomal dominant syndrome characterized by a constellation of benign skin follicle tumors, multiple renal cell neoplasms, and spontaneous pneumothorax Clinical features Epidemiology Rare autosomal dominant disease with an incidence of 1/36,000 to 1/45,000 Life risk for renal cell…

Renal cell carcinoma in von Hippel-Lindau disease

Definition An autosomal dominant disease caused by germline mutations in the von Hippel-Lindau ( VHL ) tumor suppressor gene on 3p25.3 and characterized by a constellation of tumors including renal cysts and clear cell renal cell carcinoma Clinical features Epidemiology…

Tubulocystic carcinoma

Definition A renal carcinoma with predominantly tubulocystic structures Clinical features Epidemiology A rare variant of kidney epithelial neoplasm, <1% of renal cell carcinomas Patients range in age from 30 to 80 years (mean age, 57.2 years) Male predominance with an…

Renal oncocytoma

Definition Benign renal epithelial neoplasm composed of large round-to-polygonal cells with abundant mitochondria-rich eosinophilic cytoplasm Clinical features Epidemiology 4%–8% of adult renal epithelial neoplasms in surgical pathology Wide range of age distribution with a peak incidence in the seventh decade…

Lipid-rich urothelial carcinoma

Definition A rare variant of urothelial carcinoma, characterized by the presence of lipoblast-like epithelial tumor cells with lipid-containing cytoplasmic vacuoles Clinical features You’re Reading a Preview Become a Clinical Tree membership for Full access and enjoy Unlimited articles Become membership…