Introduction Oral irreversible inhibitors of the intracellular enzyme, monoamine oxidase, have been in clinical use for over 60 years. As a group, they constitute the oldest class of antidepressants. The monoamine oxidase inhibitors (MAOIs) were developed decades ago out of…
Introduction As a group, the tricyclic antidepressants (TCAs) comprise the second-oldest class of antidepressants, beginning with the serendipitous discovery in the late 1950s that imipramine, investigated initially for its sedative properties, was effective for patients with severely depressed mood, marked…
Introduction Depression affects more than 264 million people worldwide ( ), making it one of the most prevalent of all medical conditions ( ). The sheer prevalence of depression is troubling, in and of itself. It is a chronic, relapsing…