Introduction Drug-induced thrombocytopenia (DIT) is a common clinical problem, and numerous drugs have been implicated in the development of thrombocytopenia. The risk of thrombocytopenia after any drug is low, and only a small number of patients taking a suspected medication…
Introduction Immune thrombocytopenia (ITP) is a bleeding disorder characterized by immune-mediated platelet destruction with resultant thrombocytopenia and mucocutaneous bleeding. Chronic ITP is defined by ITP persistence beyond 12 months, with spontaneous recovery occurring in less than 10% of adults. The…
Immune thrombocytopenia (ITP) is a bleeding disorder characterized by immune-mediated platelet destruction and resultant thrombocytopenia. Two forms of ITP had been described previously: acute ITP that resolves within 6 months and chronic ITP that persists beyond 6 months. Recently, an…
This chapter will focus on the acquired etiologies of neonatal thrombocytopenia as congenital and alloimmune thrombocytopenias are discussed in Chapter 93, Chapter 94 . Neonatal thrombocytopenia occurs in 1%–2% of healthy term neonates but is common in the neonatal intensive…
Fetal and neonatal alloimmune thrombocytopenia (FNAIT) is characterized by the presence of transient isolated neonatal thrombocytopenia secondary to maternal antibodies against paternally inherited antigens expressed on the fetal platelets. FNAIT is the most common cause of severe thrombocytopenia (<50,000/μL) in…