Overview The Precursor-Cancer Connection The concept of adenocarcinoma in situ (AIS) was first proposed in 1953 by Friedell and McKay on the basis of two cases of cervical adenocarcinoma that also appeared to contain a noninvasive precursor lesion. However, in…
Introduction Definition Cervical squamous neoplasia is defined as all squamous cell alterations that occur in or near the cervical transformation zone and are causally related to human papillomavirus (HPV) infections. The terms cervical intraepithelial neoplasia (CIN), dysplasia, and squamous intraepithelial…
Introduction This chapter focuses on pure squamous lesions of the vulva and focuses on three general categories, including benign common human papillomavirus (HPV) associated lesions (condylomata), two accepted and one rather newly appreciated category of preinvasive squamous neoplasia, and the…