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Introduction The three most common liver syndromes with a putative autoimmune cause are autoimmune hepatitis (AIH), primary biliary cholangitis (PBC), and primary sclerosing cholangitis (PSC). Overlap syndromes involve various combinations of these disorders. Other chronic cholestatic disorders discussed in this…

Introduction This chapter discusses a range of inflammatory and other nonneoplastic diseases of the pancreas, with a focus on variants of chronic pancreatitis that mimic pancreatic neoplasia including autoimmune pancreatitis (AIP) and paraduodenal pancreatitis. In the past, a generic diagnosis…

Introduction The gastrointestinal (GI) tract is a rich lymphoid organ by virtue of the fact that there are numerous immune cells in the lamina propria as well as abundant lymphoid follicles and Peyer’s patches distributed throughout, which is collectively referred…

The identification of infection in biopsied tissues is the primary responsibility of the surgical pathologist. In an age when both noninvasive and minimally invasive approaches and techniques have increased, it is important to revisit the role of the biopsy in…