Introduction From their initial emergence in the yolk sac at the beginning stages of embryogenesis to their vast proliferation in the bone marrow at the end of term gestation, the differentiation of the pluripotent hematopoietic stem cell into a mature,…
Acknowledgment The authors are indebted to Rachel C. Orscheln, Henry R. Shinefield, and Joseph W. St. Geme III, whose previous contributions to this chapter and clinical images provided the strong baseline framework and inspiration for the current version. Staphylococcal disease…
Lancefield group B β-hemolytic streptococci were first recorded as a cause of human infection in 1938, when Fry described three patients with fatal puerperal sepsis. Sporadic cases were reported until the 1970s, when a dramatic increase in the incidence of…
Infections of the Liver Bacterial infection of the hepatic parenchyma frequently is recognized as multiple, small inflammatory foci (hepatic microabscesses) observed as an incidental finding in infants dying with sepsis. Diffuse hepatocellular damage, often in conjunction with infection of several…
Acknowledgment Drs. S. Michael Marcy, Carol Baker and Debra L. Palazzi contributed to this chapter in earlier editions. The authors are indebted to these scholars for their roles in the preparation of this chapter. Bacterial sepsis in the neonate is…
Overview Current concepts of pathogenesis, microbiology, diagnosis, and management of infections of the fetus and newborn are reviewed in this chapter with the goal of providing a brief synthesis and overview. Information within this chapter regarding specific infections or syndromes…