Cysts Follicular (‘Epidermoid’) Cyst Definition Follicular cyst is a cystic dilatation of the hair follicle epithelium. Clinical Features Follicular cyst presents as a solitary, creamy-white or yellowish lesion on the labium majus ( Figure 5.1 ). It is generally asymptomatic,…
Extramammary Paget Disease Extramammary Paget disease (EMPD) is defined as an intraepithelial adenocarcinoma that primarily involves the epidermis outside the breast. Clinical Features This lesion accounts for only 1% of vulvar cancers. EMPD typically occurs in postmenopausal white women and…
Overview The skin is a complex microenvironment. The normal structures of the epidermis, dermis, and cutaneous adnexa are morphologically and functionally complicated, and the histologic entities that occur in this tissue compartment are also numerous. Furthermore, cutaneous lesions may also…
Overview Melanoma continues to represent one of the greatest diagnostic challenges in surgical pathology and is an important source of litigation. Both as a primary lesion in the skin and in metastatic sites, this neoplasm is capable of assuming many…
Adnexal tumors or tumorous proliferations are generally classified according to two principles, (1) benign versus malignant and (2) line of differentiation, that is, which normal cutaneous structure the lesion most resembles (hair follicle, apocrine or eccrine gland, or sebaceous gland).…