Etiology The exact pathogenesis of bile duct carcinoma has not been described, but predisposing factors are similar to those causing intrahepatic bile duct neoplasms. It is believed that long-standing inflammation causes metaplasia and, finally, carcinogenesis. Prevalence and Epidemiology Tumors of…
Etiology The exact pathogenesis of bile duct carcinoma has not been described, but predisposing factors include long-standing inflammation, parasitic infestation, toxin and drug exposures, and genetic abnormalities. It is believed that repeated inflammation leads to chronic bile duct injury with…
Etiology The precise cause of gallbladder carcinoma is unknown, but cholelithiasis and pancreaticobiliary malformations are major risk factors. Gallstones and reflux of pancreaticobiliary enzymes are thought to result in chronic repetitive inflammation of the gallbladder mucosa that, over time, may…