Abstract Background Leukocytes comprise a wide variety of cell types, and evaluation of these components is critical in medical and clinical laboratory practice. Although sensitive laboratory methods may offer strong clues about leukocyte abnormalities, accurate morphologic evaluation of these cells…
Abstract Background The roots of automated hematology began with manual microscopy and laborious cell counting techniques. Using the Coulter principle and advances in laboratory methodology, automated hematology is now rapid and inexpensive with the complete blood cell count (CBC) being…
The most common subtype of cutaneous mastocytosis, termed urticaria pigmentosa, was first described in the 19th century, a decade before mast cells (MCs) were defined by Paul Ehrlich as metachromatic cells of the connective tissue. In 1949, the first histologic…