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Diagnosis and treatment of anaplastic lymphoma kinase (ALK) rearranged non−small cell lung cancer
CLINICAL PEARLS Testing for ALK rearrangement can be performed by using immunohistochemistry, fluorescence in-situ hybridization, and next-generation sequencing. All patients with stage 4 non–small cell lung cancer with adenocarcinoma histology should be tested for an ALK rearrangement. Next-generation ALK tyrosine…