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CAR 2.0: The Next Generation of Synthetic Receptor–Based Cellular Therapy for Cancer
Introduction The growing clinical experience with chimeric antigen receptor (CAR) T-cells targeting CD19 has indicated that this therapy can induce remission in a high percentage of relapsed and refractory patients with B-cell precursor acute lymphoblastic leukemia (BCP-ALL) or B-cell non-Hodgkin's…