The admonition that “children are not small adults” is well justified in the immunosuppressive management of children after liver transplantation. When compared with adults, several key differences are apparent when considering immunosuppression for children: Children are more immunoresponsive than adults.…
Liver transplantation has made possible the functional cure of several metabolic diseases characterized by inherited genetic defects. In many pediatric transplantation centers, metabolic diseases, most notably α 1 -antitrypsin deficiency, are the second or third most common indication for liver…
Immunological Mechanisms of Rejection Transplantation of an allograft induces a formidable immunological response by the recipient designed to destroy the foreign organ efficiently and quickly. Successfully controlling this complex multifaceted cascade is the critical element required for graft survival. It…