Introduction Clinical presentations of endocrine disease can vary widely. Alterations in hormone balance can result in distinct phenotypes affecting linear growth, timing of puberty, and body composition as well as metabolic functions. The steady stream of discoveries of new genes,…
Introduction Throughout history, humans have sought to understand the differences between biological sexes and the mechanisms responsible for these biological differences. Normal gonadal differentiation and sex development depend on the meticulous choreography and synchrony of a network of endocrine, paracrine,…
Introduction Puberty in humans is defined as the period of first becoming capable of reproducing and is distinguished by maturation of the genital organs, development of secondary sex characteristics, acceleration in linear growth velocity, changes in affect, and the occurrence…