Scott T. Avecilla MD PhD Archives

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Laboratory Monitoring for Heparins, Fondaparinux, Direct Thrombin Inhibitors, and Oral Anti-Xa Medications

Laboratory testing modalities and recommendations for monitoring heparin, heparin-like medications, direct thrombin inhibitors (DTIs), and direct anti-Xa inhibitors (DXIs), including indications, testing recommendations, testing modalities, and test limitations are discussed below. There are several options available for laboratory monitoring of…

Transfusion Management of Patients Receiving Antithrombotic Therapy

Hemostasis is the process by which blood components work in concert to halt bleeding as a consequence of injury. A blood clot forms in two general phases called primary and secondary hemostasis. Primary hemostasis involves the exposure of collagen in…

Coagulation Factor Products

Patients with coagulation factor deficiencies were first treated with plasma products, but a wide variety of human-, animal-, and laboratory-derived products now exist for safer, more effective treatment. Each coagulation factor product differs in its composition, major indication, and dosage…

Human Platelet Antigens

Platelet-specific antigens associated with the formation of alloantibodies in exposed patients are the basis for human platelet antigen (HPA) categorization. Over the years, these antigenic determinants have been mapped to a relatively short list of platelet-expressed adhesion/aggregation molecules, namely GPIa,…