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Acknowledgments This work was partly supported by NIH grant U54 HD090259. Introduction Rapid and complex changes in physiology occur when the fetus transitions from an intrauterine to an extrauterine environment. From dependency on the maternal circulation via the placenta for…
Kidney development begins with interactions between the ureteric bud, an epithelial outgrowth of the Wolffian duct, and the surrounding metanephric mesenchyme. These mutually inductive interactions results in formation of the branched collecting system from the ureteric bud and most of…