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A wide variety of mitochondrial disorders are associated with liver disease. Hepatocytes contain a high density of mitochondria because the liver, with its biosynthetic and detoxifying functions, is highly dependent on adenosine triphosphate. Defects in mitochondrial function can lead to…
Cholestasis, a potentially serious condition that indicates hepatobiliary dysfunction, is defined as a serum conjugated bilirubin fraction greater than 1.0 mg/dL if the total serum bilirubin level is less than 5 mg/dL, or a value of conjugated bilirubin more than…