Monoclonal gammopathy of undetermined significance (MGUS) is a premalignant clonal plasma cell disorder. It is characterized by the presence of a monoclonal (M) protein in the serum or urine that is commonly discovered during laboratory work-up of a variety disorders.…
Definition Plasma cell disorders are neoplastic or potentially neoplastic diseases associated with the clonal proliferation of immunoglobulin-secreting plasma cells ( Table 173-1 ). These disorders are characterized by the secretion of electrophoretically and immunologically homogeneous (monoclonal) proteins that represent intact…
Monoclonal gammopathy of undetermined significance (MGUS) is a premalignant clonal plasma cell disorder. It is characterized by the presence of a monoclonal (M) protein in the serum or urine that is commonly discovered during laboratory work-up of a variety disorders.…
Summary of Key Points Multiple Myeloma Multiple myeloma accounts for approximately 10% of hematologic malignancies. Approximately 30,000 new cases are estimated to occur each year in the United States. In almost all patients, multiple myeloma is thought to evolve from…