Acknowledgment We thank Dott Antonina Minniti for her help in preparing the manuscript. The introduction of biological treatments that target leukocytes and their cytokine products has led to a major change in the management of immune-mediated inflammatory diseases, among them…
1 Introduction The formation of periductal lymphocytic infiltrates within the inflamed salivary glands represents the histological hallmark of primary Sjögren’s syndrome (pSS). Lymphomonocytic aggregates can spread within the tissue, affecting salivary gland morphology and function. On a discrete percentage of…
1 Introduction Sjögren’s syndrome (SS) is a systemic, chronic, autoimmune, inflammatory condition involving the exocrine glands. First defined as “autoimmune epithelitis” by Moutsopoulos, SS is characterized by the presence of lymphocyte infiltrates in glandular tissue that might lead, over time,…