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Fetal and Neonatal Bilirubin Metabolism
Introduction Bilirubin, a neurotoxic pigment, is the end product of heme catabolism in mammals. In adults, bilirubin is extensively metabolized by hepatic UDP-glucuronosyltransferase (UGT) 1A1 and thereby cleared from the body almost immediately. Expression and function of UGT1A1 is much…