Physical Address
304 North Cardinal St.
Dorchester Center, MA 02124
Molecular mechanisms of calcific aortic valve disease
Key points Calcific aortic valve disease is an active, highly regulated process. The initiation phase has several similarities to atherosclerosis, including endothelial injury, inflammatory cell infiltration, and lipid oxidation. Valve interstitial cell activation leads to pathologic extracellular matrix remodeling and…