Introduction Many primary connective tissue disorders alter the radiographic appearance of the skeleton and are referred to as skeletal dysplasias (see Chapter 49 ). A smaller number of disorders produce connective tissue laxity syndromes, such as the Ehlers–Danlos syndrome, in…
Definition and Classification Inflammatory bowel disease (IBD) denotes a group of related and heterogeneous disorders characterized by chronic intestinal inflammation and generally classified into Crohn disease (CD) and ulcerative colitis (UC). When there are features of both UC and CD,…
Historical Aspects Pediatric rheumatology, the study and treatment of acute and chronic diseases of the musculoskeletal system, blood vessels, and other tissues, originated in the first half of the 20th century, principally as a study of chronic inflammatory arthritis, the…