Editors' comment: Following the retirement of Dr. Gary Cunningham from our editorial team after the fourth edition of Chesley's textbook, we have taken the opportunity to update this important chapter on platelet function, coagulation, and hepatic pathophysiology in pregnancy and…
Editors' comment : It was not until the early 1980s that physicians and scientists gained an appreciation of the physiological importance of the endothelium, the simple unicellular layer lining the luminal surface of blood vessels. Indeed, in Chesley's first, single-authored…
Editors' comment: When Chesley wrote his original monograph, he, like most of the scientific community, was unfamiliar with the concept of angiogenesis. Even in the multiauthored second edition, in which the endothelial cell hypothesis of preeclampsia was first proposed, the…
Editors' comment : In Chesley's single-authored first edition, there was limited information regarding immunology and preeclampsia. He did note that as early as 1902, Viet had proposed that deported trophoblastic fragments were antigenic and could elicit antibodies that he named…
Acknowledgments The authors gratefully acknowledge the input of their clinical and research colleagues over the years that have helped shape their views and to funders including The Wellcome Trust, Medical Research Council, Tommy's and Wellbeing of Women, who have supported…
Editors' comment : Case reports describing familial clustering of eclampsia were first reported in the late 1800s, but Chesley was one of the first to perform a true genetic analysis. Chesley's first edition text summarized his early investigations in hundreds…
Editors ' comment: When Leon Chesley's Hypertensive Disorders in Pregnancy was initially published in 1978 , as now, hypertension complicating pregnancy was a major cause of fetal and maternal morbidity and death. Most of this morbidity was and remains associated…