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Introduction Pharmacokinetics describes the absorption, distribution, metabolism, and excretion of drugs. The pharmacokinetic parameters of a drug are used to characterize the drug concentrations reached within the body after a dose and the changes in those concentrations over time. Clinical…
Key Points The key feature of neonatal physiology is rapid maturation, resulting in extensive variability in pharmacokinetics and pharmacodynamics, further aggravated by other covariates, like pharmacogenetics or unique disease characteristics. Variability is the essence of neonatal care and neonatal pharmacology.…