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Complement-Mediated Coagulation Disorders: Paroxysmal Nocturnal Hemoglobinuria and Atypical Hemolytic Uremic Syndrome
Introduction Complement is an elaborate system that participates in the innate immune response. Mutations and autoantibodies leading to unregulated complement activation are implicated in the pathogenesis of a variety of human diseases. Among them, paroxysmal nocturnal hemoglobinuria (PNH) and atypical…