Objectives This chapter will: 1. Discuss acute kidney injury as a frequent complication in patients with sepsis that is associated with a high risk of mortality. 2. Review our current understanding of the pathophysiology of sepsis-induced acute kidney injury, highlighting…
Objectives This chapter will: 1. Review the principles of continuous renal replacement therapy. 2. Discuss the practical application of continuous renal replacement therapy and the consequences of such application. 3. Examine the consequences of technical modifications to continuous renal replacement…
Objectives This chapter will: 1. Describe the main dimensions of renal replacement therapy (RRT) dose: efficiency, intensity, and clinical efficacy. 2. Describe the most important studies addressing the impact of RRT dose on the survival of critically ill patients. 3.…
Objectives This chapter will: 1. Introduce the concept of blood purification. 2. Explain the mechanisms of blood purification in sepsis. 3. Evaluate the commonly used blood purification technologies. 4. Discuss the limitations and future directions of blood purification technologies. Extracorporeal…
Objectives This chapter will: 1. Highlight the very high mortality rates of patients who receive renal replacement therapy for septic acute kidney injury. 2. Appraise renal replacement modes, clearance techniques, doses, and optimal time to commence treatment in septic acute…
Objectives This chapter will: 1. Describe the nature of stress-induced hyperglycemia. 2. Explore the possible significance of normoglycemia in critically ill patients. 3. Discuss the importance of blood glucose control and nutritional support. 4. Describe the risk and incidence of…
Introduction The kidney plays a key role in maintaining solute, water, and acid-base homeostasis. Some or all of these roles may be impaired in critically ill patients because of processes that disrupt glomerular, tubular, or interstitial function. This chapter will…