Tag Richard B. Johnston

Complement is an exquisitely balanced, highly influential system that is fundamental to the clinical expression of host defense and inflammation. The complement system also has the capacity to perform functions beyond host defense, such as promoting phagocytic removal of dying…

Mononuclear phagocytes (monocytes, macrophages) are distributed across all body tissues and play a central role in maintaining immunologic and metabolic homeostasis. They are essential for innate host defense against infection, tissue repair and remodeling, and the antigen-specific adaptive immune response.…