1 Why is it important to understand complications after allogeneic hematopoietic cell transplantation? Allogeneic hematopoietic cell transplantation (AlloHCT) is a lengthy and complex process. The majority of the patients sustain complications after AlloHCT. These complications can have a significant impact…
1 What are chimeric antigen receptor–T cells? Chimeric antigen receptor (CAR)-T cells are a powerful form of adoptive cell therapy. In their native state, T cells do not express antigens targeted to bind to malignant cells. In CAR-T therapy, T…
1 Describe the types of transplant and their indications. Type of Transplant Details of Transplant Indications Disadvantages Autologous hematopoietic stem cell transplantation (autoHCT) Use patient’s own hematopoietic cells. Give granulocyte colony-stimulating factor (G-CSF) and/or Plerixafor to mobilize cells to collect.…
1 What is the definition of hemophagocytic lymphohistiocytosis? Hemophagocytic lymphohistiocytosis (HLH) is a rare but potentially fatal clinical syndrome of severe pathologic immune activation, characterized by signs and symptoms of excessive inflammation. It commonly appears in infancy but can be…