This chapter focuses on central nervous system (CNS) physiology and pharmacology relevant to anesthesiology. The molecular and cellular substrates of specific drugs affecting the nervous system are covered in Chapter 8 and in the appropriate chapters in this section. Cerebrovascular…
Key Points ▪ For the purposes of planning a strategy for controlling intracranial pressure (ICP), the four subcompartments of the intracranial space should be considered: cells, interstitial and intracellular fluid, cerebrospinal fluid (CSF), and blood. ▪ The clinician should make…
Key Points ▪ The brain has a high metabolic rate and receives approximately 12% to 15% of cardiac output. Under normal circumstances, cerebral blood flow (CBF) is approximately 50 mL/100 g Gray matter receives 80% and white matter receives 20%…