Paul Ehrlich used his 1878 doctoral thesis to characterize a new cell type—the mast cell (MC)—based on its reactivity to aniline dyes and the metachromatic appearance of its cytoplasmic granules. He referred to MCs as Mastzellen and he speculated that…
Eosinophils are highly specialized granulocytic effector cells that produce and store numerous biologically active mediators, including cytotoxic proteins, lipid mediators, chemotactic peptides, and cytokines ( Table 74.1 ). Under various pathologic conditions, blood eosinophils transmigrate through the endothelial layer and…
Paul Ehrlich used his 1878 doctoral thesis to characterize a new cell type—the mast cell (MC)—based on its reactivity to aniline dyes and the metachromatic appearance of its cytoplasmic granules. He referred to MCs as Mastzellen and he speculated that…
Eosinophils are highly specialized granulocytic effector cells that produce and store numerous biologically active mediators, including cytotoxic proteins, lipid mediators, chemotactic peptides, and cytokines ( Table 74.1 ). Under various pathologic conditions, blood eosinophils transmigrate through the endothelial layer and…
The most common subtype of cutaneous mastocytosis, termed urticaria pigmentosa, was first described in the 19th century, a decade before mast cells (MCs) were defined by Paul Ehrlich as metachromatic cells of the connective tissue. In 1949, the first histologic…