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Acknowledgments Original work described here was supported by NIH grants: DK069998 and DK105811 (PAF); DK087688 and DK102495 (JPV). The authors declare that they have no financial or other conflicts of interest. 1 Biosynthesis and Metabolism The chief cells of the…
Although bone harbors almost all of the body stores of calcium, the kidneys serve as the regulator of calcium homeostasis. Calcium filtered at the glomerulus is extensively reabsorbed by proximal tubules. This recovery proceeds without hormonal regulation and is governed…