Hereditary Vascular Malformations Hereditary Hemorrhagic Telangiectasia (Osler–Weber–Rendu Disease) Hereditary hemorrhagic telangiectasia (HHT) is a systemic autosomal dominant (AD) vascular disease that is characterized by mucocutaneous telangiectasias and multiple arteriovenous malformations (AVMs). It is the most common inherited vascular bleeding disorder…
Delayed hemolytic transfusion reactions (DHTRs) typically occur 3–10 days after red blood cell (RBC) transfusion that appear to be serologically compatible. These reactions occur in patients who have been alloimmunized to minor RBC antigens during previous transfusions and/or pregnancies; pretransfusion…
Red Blood Cell Transfusions RBC Transfusion Considerations in Neonates Neonatal RBC transfusion thresholds are not clearly defined, with gestational age, postnatal age, and clinical condition being important considerations. Two randomized control trials (RCTs) (Bell et al. and Kirpalani et al.) comparing liberal…
Volume reduction (also known as hyperpacking or hyperconcentrating), a process performed after a blood component has been manufactured, is the removal of a portion of supernatant of a cellular blood product, such as red blood cell (RBC) or platelet unit.…