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Introduction Clinical presentations of endocrine disease can vary widely. Alterations in hormone balance can result in distinct phenotypes affecting linear growth, timing of puberty, and body composition as well as metabolic functions. The steady stream of discoveries of new genes,…
Introduction and Background In the fully developed organism, growth hormone (GH), a 22-kDa molecule of 191 amino acids, is synthesized by acidophil cells in the anterior pituitary gland under the direction of hypothalamic GH-releasing hormone, which binds to its G…