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The Pathogen Hepatitis A virus (HAV) is a positive-sense RNA virus and a member of the Picornaviridae family. The single-stranded RNA genome is approximately 7500 nucleotides long and contains a single open reading frame. The encoded polyprotein includes structural proteins…
INTRODUCTION History of Hepatitis A Disease Contagious jaundice was initially recognized independently in Europe—by the Greeks at the time of Hippocrates—and in Asia, by the Chinese ; however, the earliest recorded outbreaks of jaundice that appear epidemiologically to have been…