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Orthotopic liver transplantation (OLT) for malignancy, specifically hepatocellular carcinoma (HCC), has dramatically increased in the last several decades. Unfortunately, cancer recurrence remains a formidable problem. At present, calcineurin-based immunosuppression (IS) regimens are employed by most transplant centers around the world.…
Necrotic liver tissue, whether before or after liver transplantation, is a serious condition that requires immediate attention, because it can result in considerable morbidity or mortality. Although the most effective treatment for a massively necrotic liver is liver replacement, the…
Fifty years have passed since the first liver transplantation was performed by Thomas E. Starzl. Orthotopic liver transplantation (OLT) has become the recommended treatment in patients with hepatocellular carcinoma (HCC) and cirrhosis, as well as for other selected tumors. This…