Nicholas F. LaRusso Archives

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Dorchester Center, MA 02124

Overview Primary sclerosing cholangitis (PSC) is a chronic, idiopathic cholangiopathy characterized histologically by peribiliary inflammation and fibrosis. PSC can progress to cirrhosis and is a risk factor for hepatobiliary and colonic carcinogenesis. The median liver transplant (LT) free survival time…

Physiology of Cholngiocytes

Cholangiocytes are epithelial cells that line the biliary tree, a complex, three-dimensional network of interconnecting intrahepatic and extrahepatic bile ducts. The main physiologic function of cholangiocytes is the modification of the bile within the ductal lumen via coordinated bidirectional vectorial…