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Review of the Current Knowledge Base of the Topic Direct intracerebral infusion of neurotrophic factors may represent a neuroprotective and neurorestorative therapeutic strategy for neurodegenerative movement disorders, most notably Parkinson’s disease (PD). A number of neurotrophins, including glial cell-line-derived neurotrophic…
Relevant History of the Topic Including Developments Over the Past Decade The application of neurostimulation to the management of chronic pain syndromes remains a significant challenge for chronic pain specialists. The origins of deep brain stimulation for intractable pain can…