Aplastic anemia (AA), the paradigm of the bone marrow (BM) failure syndromes, is most simply defined as peripheral blood pancytopenia and a hypocellular BM ( Fig. 31.1 ). AA occurring as a primary hematologic disorder is historically denoted idiopathic, but…
Definition B19 parvovirus, which was discovered in the mid-1970s by electron microscopy of an anomalous precipitin reaction of a blood donor’s serum (occupying position 19 in plate B), was first linked to human disease by the observation of virus-specific immunoglobulin…
Aplastic anemia (AA), the paradigm of the bone marrow (BM) failure syndromes, is most simply defined as peripheral blood pancytopenia and a hypocellular BM ( Fig. 31.1 ). AA occurring as a primary hematologic disorder is historically denoted idiopathic, but…