Autoimmune encephalitis with antibodies to neuronal cell surface/synaptic antigens (further referred to as autoimmune encephalitis) are a group of neuropsychiatric disorders ( Table 82.1 ) in which the antibodies produce neuronal dysfunction by direct interaction with their target antigen (…
Pathogenesis Paraneoplastic neurological syndromes (PNSs) are a heterogeneous group of disorders that are immune mediated ( Table 81.1 ). It is postulated that the expression of neuronal proteins (called onconeuronal proteins) by a tumor provokes an immune response that is…
Summary of Key Points The paraneoplastic neurologic syndromes include an extensive group of immune-mediated disorders that can affect any part of the central or peripheral nervous system. Patients with paraneoplastic neurologic syndromes may have serum and cerebrospinal fluid antibodies that…